Friendly Vitamins - IP6
Thursday, March 25, 2010 at 10:01PM In the NEWS right now, Inositol and IP6 stop lung cancer growth or development in 5-6 out of 10 cases. OK, yes this was just an animal study. 
Next is one of the research studies of IP6 on prostate cancers:
Inositol Hexaphosphate Suppresses Growth and Induces Apoptosis in Prostate Carcinoma Cells in Culture and Nude Mouse Xenograft: PI3K-Akt Pathway as Potential Target
Mallikarjuna Gu1, Srirupa Roy1, Komal Raina1, Chapla Agarwal1,2 and Rajesh Agarwal1,2
1 Department of Pharmaceutical Sciences, School of Pharmacy, and 2 University of Colorado Cancer Center, University of Colorado-Denver, Aurora, Colorado
"...3-kinase (PI3K)-Akt pathway transmits growth-regulatory signals that play a central role in promoting survival, proliferation, and angiogenesis in human prostate cancer cells. Here, we assessed the efficacy of inositol hexaphosphate (IP6) against invasive human prostate cancer PC-3 and C4-2B cells and regulation of PI3K-Akt pathway. IP6 treatment of cells suppressed proliferation, induced apoptosis ... Efficacy studies employing PC-3 tumor xenograft growth in nude mice showed that 2% (w/v) IP6 feeding in drinking water inhibits tumor growth and weight by 52% to 59% (P < 0.001). Immunohistochemical analysis of xenografts showed that IP6 significantly reduces the expression of molecules associated with cell survival/proliferation (ILK1, phosphorylated Akt, cyclin D1, and proliferating cell nuclear antigen) and angiogenesis (platelet endothelial cell adhesion molecule-1 or CD31, vascular endothelial growth factor, endothelial nitric oxide synthase, and hypoxia-inducible factor-1
) together with an increase in apoptotic markers. These findings suggest that, by targeting the PI3K-ILK1-Akt pathway, IP6 suppresses cell survival, proliferation, and angiogenesis but induces death in prostate cancer cells, which might have translational potential in preventing and controlling the growth of advanced and aggressive prostate cancer for which conventional chemotherapy is not effective. [Cancer Res 2009;69(24):9465–72]
Valuable stuff this IP6 which is available as a supplement at many health food and vitamin stores, and in some whole foods. Also called phytates, IP6 has the affinity to chelate, or bind up, heavy metals and maybe other minerals too, like iron. Obviously, moderation is needed to manage it's mineral binding process, but look at these other results; ref ref ref ref ref IP6 is naturally found in whole grain brown rice. ref
Precaution: Best to take IP6 separate from vital minerals due to this binding action on minerals like calcium, magnesium, zinc, iron, and manganese. Children are often low in zinc when on high cereal diets. Consuming a variety of foods over the day usually negates this binding potential. But, since zinc is often low in diet, extra care should be taken for children and Seniors. ref
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